Cyclopentanone → HCID 10726798, compound

HRID 1198635Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH:5]=O.[C:11]1(=[O:16])[CH2:15][CH2:14][CH2:13][CH2:12]1>>[CH3:1][O:2][C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1/[CH:5]=[C:12]1/[C:11](=[O:16])[CH2:15][CH2:14][CH2:13]/1

Participants

Reactant 2

HCID 8452Cyclopentanone

HCID 86582-Methoxybenzaldehyde

Product 1

HCID 10726798HCID 10726798, compound

Procedure

The procedure was similar to that in Example 4 by reacting 2-methoxybenzaldehyde with the morpholine enamine of cyclopentanone to give 2-(E)-[(2-methoxy) benzylidene] cyclopentanone. The melting popint of this intermediate compound was determined to be 80°-82° C. A subsequent Mannich reaction yielded the 2-Dimethylaminomethyl-5-(E)-[(2-methoxy) benzylidene] cyclopentanone hydrochloride. The melting point of the product was determined to be 167°-169° C.

Sources & evidence

ORD record: ord-483d53159fdf4fbaba7042b9169fc375
Source dataset: uspto-grants-1994_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05281622

Reaction notes

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