Aminoethylpiperazine → HCID 67938305, compound

HRID 1198913Notes

Reaction equation

HRID 1198913 reaction equation
[O:1]=[C:2]1[NH:7][CH2:6][C:5]([C:8]2[CH:20]=[CH:19][C:11]([O:12][CH2:13][C:14]([O:16]CC)=[O:15])=[CH:10][CH:9]=2)=[N:4][NH:3]1.[N:21]1([CH2:27][CH2:28][NH2:29])[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>C(O)C>[OH2:1].[N:21]1([CH2:27][CH2:28][NH:29][C:14](=[O:16])[CH2:13][O:12][C:11]2[CH:10]=[CH:9][C:8]([C:5]3[CH2:6][NH:7][C:2](=[O:1])[NH:3][N:4]=3)=[CH:20][CH:19]=2)[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1.[N:21]1([CH2:27][CH2:28][NH:29][C:14](=[O:15])[CH2:13][O:12][C:11]2[CH:10]=[CH:9][C:8]([C:5]3[CH2:6][NH:7][C:2](=[O:1])[NH:3][N:4]=3)=[CH:20][CH:19]=2)[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1

Participants

4

Reactant 2

HCID 8795AminoethylpiperazineHCID 14099035HCID 14099035, compound

Product 1

HCID 67938305HCID 67938305, compoundYield 110.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3.05 g of ethyl α-[4-(2,3,4,5-tetrahydro-3-oxo-1,2,4-triazin-6-yl)phenoxy]acetate [prepared as described in Example 15(b) or (c) above] and 2.13 g of 2-(1-piperazinyl)ethylamine dissolved in 50 ml of ethanol was heated under reflux for 24 hours, whilst stirring. At the end of this time, the crystals which precipitated were collected by filtration and recrystallized from ethanol, to give 3 g of the title compound as colorless fine crystals melting at 177°-180° C.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 24 hours
  3. customAt the end of this time, the crystals which precipitated
  4. filtrationwere collected by filtration
  5. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-4a43f9e9567c4a72b4b3d12f07e9820d
Source dataset
uspto-grants-1990_02
Patent number
US04898862

Reaction notes

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