2-Morpholinoethylamine → HCID 14099049, compound

HRID 1198916Notes

Reaction equation

HRID 1198916 reaction equation
[CH3:1][CH:2]1[C:7]([C:8]2[CH:20]=[CH:19][C:11]([O:12][CH2:13][C:14]([O:16]CC)=O)=[CH:10][CH:9]=2)=[N:6][NH:5][C:4](=[O:21])[NH:3]1.[O:22]1[CH2:27][CH2:26][N:25]([CH2:28][CH2:29][NH2:30])[CH2:24][CH2:23]1>C(OCC)(=O)C>[O:22]1[CH2:27][CH2:26][N:25]([CH2:28][CH2:29][NH:30][C:14](=[O:16])[CH2:13][O:12][C:11]2[CH:10]=[CH:9][C:8]([C:7]3[CH:2]([CH3:1])[NH:3][C:4](=[O:21])[NH:5][N:6]=3)=[CH:20][CH:19]=2)[CH2:24][CH2:23]1

Participants

4

Reactant 2

HCID 4082852-MorpholinoethylamineHCID 14099036HCID 14099036, compound

Product 1

HCID 14099049HCID 14099049, compoundYield 69.8%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

0.4 g of ethyl α-[4-(2,3,4,5-tetrahydro-5-methyl-3-oxo-1,2,4-triazin-6-yl)phenoxy]acetate (prepared as described in Example 18) was mixed with 0.36 g of 2-morpholinoethylamine, and the mixture was stirred at 115° to 120° C. for 1 hour. The mixture was then cooled, and ethyl acetate was added. The crystals which precipitated were collected by filtration and washed with ethyl acetate to give a pale yellow powder. Recrystallization of this powder from ethyl acetate gave 0.36 g of the title compound as pale brown, fine crystals melting at 147°-149° C.

Workup

  1. temperatureThe mixture was then cooled
  2. customThe crystals which precipitated
  3. filtrationwere collected by filtration
  4. washwashed with ethyl acetate
  5. customto give a pale yellow powder
  6. customRecrystallization of this powder from ethyl acetate

Sources & evidence

ORD record
ord-3bb41920de0b427db788e4332e7350fe
Source dataset
uspto-grants-1990_02
Patent number
US04898862

Reaction notes

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