Hydrogen Peroxide → HCID 14835385, compound

HRID 1199008Notes

Reaction equation

HRID 1199008 reaction equation
OO.[NH2:3][C:4]1[C:9]([CH3:10])=[CH:8][CH:7]=[CH:6][C:5]=1[C:11]([C:13]1[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=1)=[O:12]>C(O)(=O)C>[CH3:10][C:9]1[C:4]2[C:5](=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([C:19]([F:20])([F:21])[F:22])=[CH:15][CH:14]=3)[O:12][N:3]=2)[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 14835384HCID 14835384, compound

Product 1

HCID 14835385HCID 14835385, compoundYield 13%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
70 °C

Procedure

A solution of 150 ml of 30% hydrogen peroxide and 300 ml of glacial acetic acid was heated on a steam bath for 1 hr and then cooled. The solution was treated with 26.3 g (0.094 mole) of (2-amino-3-methylphenyl) [4-(trifluoromethyl)phenyl]methanone and the mixture was heated at 70° C. for 7 hr and let stand at ambient temperature overnight. The mixture was poured into 2 liters of ice water and the solid was collected by filtration, washed with water and recrystallized from 2-propanol to yield 3.4 g (13%) of tan powder, m.p. 118°-119° C.

Workup

  1. temperaturecooled
  2. filtrationthe solid was collected by filtration
  3. washwashed with water
  4. customrecrystallized from 2-propanol

Sources & evidence

ORD record
ord-c6773209042344659382cc6dd5fb6120
Source dataset
uspto-grants-1990_02
Patent number
US04898874

Reaction notes

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