Methylamine → HCID 19867813, compound

HRID 1199026Notes

Reaction equation

HRID 1199026 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:17][C:18]([OH:20])=O)[C:5]2[C:6]([CH:16]=1)=[C:7]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[O:8][N:9]=2.[CH3:21][NH2:22]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:17][C:18]([NH:22][CH3:21])=[O:20])[C:5]2[C:6]([CH:16]=1)=[C:7]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[O:8][N:9]=2

Participants

3

Reactant 2

HCID 6329Methylamine2×HCID 14835398HCID 14835398, compound

Product 1

HCID 19867813HCID 19867813, compound

Procedure

The title compound is prepared by reacting the acid chloride of 5-chloro-3-phenyl-2,1-benzisoxazole-7-acetic acid and excess monomethylamine in a closed container in an aprotic solvent. The unused methylamine is allowed to escape and the solution is washed with hydrochloric acid followed by aqueous base and evaporated. The title compound is obtained by conventional crystallization from alkanolic solution or by chromatography.

Workup

  1. customThe title compound is prepared
  2. washthe solution is washed with hydrochloric acid
  3. customevaporated

Sources & evidence

ORD record
ord-61073b99be3844b296612526495f6d75
Source dataset
uspto-grants-1990_02
Patent number
US04898874

Reaction notes

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