Hydrochloric Acid → HCID 14835404, compound

HRID 1199070Notes

Reaction equation

HRID 1199070 reaction equation
[C:1]1([C:7]2[CH:8]=[N:9][N:10]([CH2:18][C:19]([O:21]CC)=[O:20])[C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(O)C.[OH-].[Na+].Cl>O>[C:1]1([C:7]2[CH:8]=[N:9][N:10]([CH2:18][C:19]([OH:21])=[O:20])[C:11]=2[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702Ethanol2×HCID 14798Sodium HydroxideHCID 146995514,5-Diphenyl-1-(ethoxycarbonylmethyl)-pyrazole

Product 1

HCID 14835404HCID 14835404, compoundYield 93.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

Twelve grams (0.04 mol) of ethyl 4,5-diphenyl-1-H-pyrazole-1-acetate of example 1 was refluxed in 40 mL of water, 40 mL of ethanol and 5 mL of 35% aqueous sodium hydroxide for 1.5 hours. The ethanol was stripped off, water was added, and the slurry was acidified with excess 6N HCl. The resulting precipitate was filtered off and rinsed with water to yield 10.4 g of free acid, mp 169°-170° C.

Workup

  1. filtrationThe resulting precipitate was filtered off
  2. washrinsed with water

Sources & evidence

ORD record
ord-9cbfd467f70f4b33a654aaae1db07157
Source dataset
uspto-grants-1990_02
Patent number
US04898880

Reaction notes

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