Water → Cefadroxil monohydrate

HRID 1199092Notes

Reaction equation

HRID 1199092 reaction equation
[CH3:1][C:2]1[CH2:22][S:21][C@@H:5]2[C@H:6]([NH:9][C:10]([C@H:12]([NH2:20])[C:13]3[CH:14]=[CH:15][C:16]([OH:19])=[CH:17][CH:18]=3)=[O:11])[C:7](=[O:8])[N:4]2[C:3]=1[C:23]([OH:25])=[O:24].CC(N(C)C)=[O:28].O>C(O)(C)C>[CH3:1][C:2]1[CH2:22][S:21][C@@H:5]2[C@H:6]([NH:9][C:10]([C@H:12]([NH2:20])[C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=3)=[O:11])[C:7](=[O:8])[N:4]2[C:3]=1[C:23]([OH:25])=[O:24].[OH2:28]

Participants

4

Reactant 2

HCID 962WaterHCID 14996560HCID 14996560, compound

Product 1

HCID 47964Cefadroxil monohydrate

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Cefadroxil dimethylacetamide solvate (40 g) prepared according to example 1 was slurried in isopropyl alcohol (200 ml) containing 13% of water at 50° C. for 90'. The mixture was cooled to +5° C. and cefadroxil monohydrate was collected to yield 28.5 exhibiting the same X-ray diffraction pattern of an authentic sample of crystalline cefadroxil monohydrate.

Workup

  1. temperatureThe mixture was cooled to +5° C.
  2. customcefadroxil monohydrate was collected

Sources & evidence

ORD record
ord-9ee67626a1be42f097c050d44f48f4c8
Source dataset
uspto-grants-1990_02
Patent number
US04898938

Reaction notes

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