反应详情

Into 12 ml of 6N--HCl solution was dissolved 4.65 g of N-phenylmorpholine. To the solution was added 1.5 g of pyruvic acid and the mixture was heated with reflux for 20 hours. The reaction mixture was, after cooled, diluted with 100 ml of water and adjusted to pH 6 with addition of 20% aqueous solution of sodium hydroxide. The precipitated crystal was collected by filtration which was 3.75 g (yield 66%) of 2,2-bis(4-morpholinophenyl)propionic acid, having a melting point of 217°~223° C.

1. temperaturethe mixture was heated
2. temperaturewith reflux for 20 hours
3. temperatureafter cooled
4. filtrationThe precipitated crystal was collected by filtration which