反应详情

Into 6.0 ml of 6N--HCl solution was dissolved 4.2 g of 1-methyl-1,2,3,4-tetrahydroquinoline. To the solution was added 3 g of pyruvic acid and the mixture was heated with reflux for 20 hours. The reaction mixture was, after cooled, diluted with 100 ml of water and adjusted to pH 6 with addition of 20% aqueous solution of sodium hydroxide. The precipitated crystal was collected by filtration which was 4.0 g (yield 77%) of 2,2-bis(1-methyl-1,2,3,4-tetrahydroquinoline-6-yl)propionic acid as light brown crystal, having a melting point of 155°~157° C.

1. temperaturethe mixture was heated
2. temperaturewith reflux for 20 hours
3. temperatureafter cooled
4. filtrationThe precipitated crystal was collected by filtration which