Anisole → HCID 178503585, compound

HRID 1199348Notes

Reaction equation

HRID 1199348 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6](=[CH:12][CH:13]=1)[N:7]=[C:8]([S:10][CH3:11])[N:9]=2.[C:14]1(OC)C=CC=CC=1.[F:22][C:23]([F:30])([F:29])[S:24]([O:27]C)(=[O:26])=[O:25]>C(OCC)(=O)C>[F:22][C:23]([F:30])([F:29])[S:24]([O-:27])(=[O:26])=[O:25].[CH3:14][N:9]1[C:5]2=[CH:4][CH:3]=[C:2]([CH3:1])[CH:13]=[CH:12][C:6]2=[NH+:7][CH:8]1[S:10][CH3:11]

Participants

5

Reactant 3

HCID 7519AnisoleHCID 9526Methyl triflateHCID 200643756-Methyl-2-(methylsulfanyl)cyclohepta[d]imidazole

Product 1

HCID 178503585HCID 178503585, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

6-Methyl-2-methylthiocycloheptimidazole (27 g) was added to 100 ml of anisole and stirred under ice cooling. Then, 28 g of methyl trifluoromethanesulfonate was added dropwise thereto, and stirred under ice cooling. The mixture was further stirred at room temperature for one hour, 200 ml of ethyl acetate was added, and deposited crystals were collected by filtration and dried.

Workup

  1. stirringstirred under ice cooling
  2. stirringThe mixture was further stirred at room temperature for one hour
  3. filtrationwere collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-a7d3fe9e3ec64f6fab616d0207dc7023
Source dataset
uspto-grants-1990_02
Patent number
US04900648

Reaction notes

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