反应详情

1-(4-Pyridoyl)-4-methylthiosemicarbazide (10.4 g, 4.97×10-2 mole) and 1 molar aqueous NaHCO3 (480 ml, 4.80×10-1 mole) were stirred and heated to reflux. After refluxing overnight, the reaction was cooled in an ice bath before being acidified by the dropwise addition of concentrated hydrochloric acid (40 ml, 4.8×10-1 mole). The product was collected by filtration and dried by suction.

1. temperatureheated to reflux
2. temperatureAfter refluxing overnight
3. temperaturethe reaction was cooled in an ice bath
4. filtrationThe product was collected by filtration
5. customdried by suction