Isopropyl isocyanate → HCID 14627711, compound

HRID 1199413Notes

Reaction equation

HRID 1199413 reaction equation
[CH3:1][C:2]1([CH3:17])[O:14][C:6]2=[CH:7][C:8]3[C:9]([CH:13]=[C:5]2[CH:4]([NH2:15])[CH:3]1[OH:16])=[N:10][O:11][N:12]=3.[CH:18]([N:21]=[C:22]=[O:23])([CH3:20])[CH3:19]>ClCCl>[CH3:1][C:2]1([CH3:17])[O:14][C:6]2=[CH:7][C:8]3[C:9]([CH:13]=[C:5]2[CH:4]([NH:15][C:22]([NH:21][CH:18]([CH3:20])[CH3:19])=[O:23])[CH:3]1[OH:16])=[N:10][O:11][N:12]=3

Participants

4

Reactant 2

HCID 61277Isopropyl isocyanateHCID 11107308(+)-7,8-dihydro-6,6-dimethyl-7-hydroxy-8-amino-6H-pyrano[2,3-f]benz-2,1,3-oxadiazole

Product 1

HCID 14627711HCID 14627711, compoundYield 44%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a mixture of 200 mg (0.850 m mol) of 7,8-dihydro-6,6-dimethyl-7-hydroxy-8-amino-6H-pyrano [2,3-f] benzo-2,1,3-oxadiazole and 20 ml of dichloromethane were added 92 μl (0.935 m mol) of isopropyl isocyanate with stirring at the room temperature, followed by stirring for 6 hours. The precipitated crystals were filtered off to obtain 120 mg (yield: 44%) of the intended compounds as colorless crystals.

Workup

  1. stirringby stirring for 6 hours
  2. filtrationThe precipitated crystals were filtered off

Sources & evidence

ORD record
ord-58755cedc6594ae7a51da9275e987bb6
Source dataset
uspto-grants-1990_02
Patent number
US04900752

Reaction notes

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