Ethyl Acetate → HCID 178493115, compound

HRID 1199457Notes

Reaction equation

HRID 1199457 reaction equation
[CH3:1][O:2][C:3]1[CH:26]=[CH:25][C:6]2[NH:7][C:8]([S:10][C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[C:17]3[CH:22]=[C:21]([O:23][CH3:24])[CH:20]=[CH:19][N:18]=3)=[N:9][C:5]=2[CH:4]=1.C(OCC)(=[O:29])C>>[CH3:1][O:2][C:3]1[CH:26]=[CH:25][C:6]2[NH:7][C:8]([S:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[C:17]3[CH:22]=[C:21]([O:23][CH3:24])[CH:20]=[CH:19][N:18]=3)=[O:29])=[N:9][C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 8857Ethyl Acetate2×HCID 178493114HCID 178493114, compound

Product 1

HCID 178493115HCID 178493115, compound

Procedure

The product of step (c) above (103 mg) was dissolved in ethyl acetate (7.5 ml) and stirred at -10° . A solution of m-chloroperbenoic acid (58 mg of 85%) in ethyl acetate (0.5 ml) was added and the mixture stirred for 50 minutes. The solution was washed with sodium bicarbonate solution, sodium bisulphite solution, water and brine then dried and evaporated. After trituration with ether the solid was dried to afford the title compound. MS (FAB) M+1 at 380.

Workup

  1. stirringthe mixture stirred for 50 minutes
  2. washThe solution was washed with sodium bicarbonate solution, sodium bisulphite solution, water and brine
  3. customthen dried
  4. customevaporated
  5. dry with materialAfter trituration with ether the solid was dried

Sources & evidence

ORD record
ord-bbdf4e326e8343b587c41f0803412e74
Source dataset
uspto-grants-1990_02
Patent number
US04900751

Reaction notes

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