Triethylamine → 1-Piperidinecarboxylic acid, 2-(2-hydroxyethyl)-, butyl ester

HRID 1199493Notes

Reaction equation

HRID 1199493 reaction equation
[OH:1][CH2:2][CH2:3][CH:4]1[CH2:9][CH2:8][CH2:7][CH2:6][NH:5]1.C(N(CC)CC)C.Cl[C:18]([O:20][CH2:21][CH2:22][CH2:23][CH3:24])=[O:19]>O1CCCC1>[CH2:21]([O:20][C:18]([N:5]1[CH2:6][CH2:7][CH2:8][CH2:9][CH:4]1[CH2:3][CH2:2][OH:1])=[O:19])[CH2:22][CH2:23][CH3:24]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 151442-Piperidin-2-ylethanolHCID 61140Butyl chloroformate

Product 1

HCID 98345201-Piperidinecarboxylic acid, 2-(2-hydroxyethyl)-, butyl ester

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

6.5 g (0.05 mol) of 2-(2-hydroxyethyl)-piperidine and 10 ml of triethylamine are dissolved in 300 ml of tetrahydrofuran, and 7.5 g (0.55 mol) of butyl chloroformate are added at -20° C.

Sources & evidence

ORD record
ord-64a8abcfb5d244c892fda0b1dcc7c8f1
Source dataset
uspto-grants-1990_02
Patent number
US04900834

Reaction notes

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