Hydrochloric Acid → HCID 14989663, compound

HRID 1199688Notes

Reaction equation

HRID 1199688 reaction equation
[C:1]1([NH:7][S:8]([C:11]2[CH:12]=[CH:13][C:14]([CH2:17][CH2:18][CH2:19][C:20]([O:22]C)=[O:21])=[N:15][CH:16]=2)(=[O:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].Cl>C(O)C>[C:1]1([NH:7][S:8]([C:11]2[CH:12]=[CH:13][C:14]([CH2:17][CH2:18][CH2:19][C:20]([OH:22])=[O:21])=[N:15][CH:16]=2)(=[O:10])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 14989661HCID 14989661, compound

Product 1

HCID 14989663HCID 14989663, compoundYield 83.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of methyl 4-[5-(phenylsulphamoyl)pyrid-2-yl]butanoate (0.7 g), 10% w/v sodium hydroxide solution (5 ml) in ethanol (10 ml) was stirred for 1 hour. The solution was acidified with dilute hydrochloric acid (pH=3) and cooled. The precipitate was collected and recrystallised from ethanol to give the title compound as prisms (0.56 g). m.p. 158°-159° C.

Workup

  1. temperaturecooled
  2. customThe precipitate was collected
  3. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-8c39cf346f074e30bd9190e513718578
Source dataset
uspto-grants-1990_02
Patent number
US04902698

Reaction notes

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