Propionic anhydride → HCID 70359626, compound

HRID 1199789Notes

Reaction equation

HRID 1199789 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH2:15][OH:16])=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:6]=2[CH:23]=1.[C:24]([O:28]C(=O)CC)(=[O:27])[CH2:25][CH3:26]>O>[C:24]([OH:28])(=[O:27])[CH2:25][CH3:26].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH2:15][OH:16])=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:6]=2[CH:23]=1

Participants

4

Reactant 2

HCID 31263Propionic anhydrideHCID 162244alpha-Hydroxyalprazolam

Product 1

HCID 70359626HCID 70359626, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In a manner similar to Example 12, a mixture of 8-chloro-1-(hydroxymethyl)-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine and propionic anhydride was heated on the water bath to give 8-chloro-1-(hydroxymethyl)-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine propionate (ester).

Sources & evidence

ORD record
ord-4549eff1c22b495eb3630253fc39fd2e
Source dataset
uspto-grants-1990_02
Patent number
US04902794

Reaction notes

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