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HRID1199815

反应详情

EQUATION

反应方程式

HRID 1199815 的结构方程式

REACTANTS

反应物

3
结构：C#C[Si](C)(C)C
HCID66111

Trimethylsilylacetylene

C5H10Si

结构：[Br-].[K+]
HCID253877

Potassium bromide

BrK

结构：CC(C)(C)C(=O)Nc1nc(O)c2cc(Br)cnc2n1
HCID178447249

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)C(=O)Nc1nc(O)c2cc(C#C[Si](C)(C)C)cnc2n1
HCID178447255

未命名化合物

收率 81%

PROCEDURE

实验过程

2-Pivaloylamino-4-hydroxy-6-trimethylsilylethynylpyrido[2,3-d]pyrimidine is prepared in 81% yield from 2-pivaloylamino-4-hydroxy-6-bromopyrido[2,3-d]pyrimidine and trimethylsilylacetylene analogously to Example 2B. m.p. >250° C.; NMR (CDCl3, 300 MHz) delta 0.29 (s, 9H), 1.35 (s, 9H), 8.36 (brs, 1H), 8.57 (d, 1H, J=2.45 Hz), 8.92 (d, 1H, J=2.45 Hz); IR (KBr) 3200, 2970, 2170, 1680, 1620, 1545, 1475, 1440, 1380, 1275, 1250, 1145, 930, and 845 cm-1.