Acetonitrile → HCID 54472884, compound

HRID 1199924Notes

Reaction equation

HRID 1199924 reaction equation
C[C:2]1[S:3][CH:4]=[CH:5][C:6]=1[CH2:7][CH2:8][NH2:9].[CH2:10]1[O:18][CH:11]1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[C:19](#N)C>>[OH:18][CH:11]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH2:10][N:9]([CH3:19])[CH2:8][CH2:7][C:6]1[CH:5]=[CH:4][S:3][CH:2]=1

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 7276Styrene OxideHCID 19826895HCID 19826895, compound

Product 1

HCID 54472884HCID 54472884, compound

Procedure

A solution of methyl thiophene-3-ethylamine (3.3 g) and styrene oxide (1.8 ml) in acetonitrile (17 ml) was heated under reflux for 24 hours. The mixture was evaporated and the residual oil chromatographed on silica eluting with 2% methanol in dichloromethane to give the title product as an oil.

Workup

  1. temperatureunder reflux for 24 hours
  2. customThe mixture was evaporated
  3. customthe residual oil chromatographed on silica eluting with 2% methanol in dichloromethane

Sources & evidence

ORD record
ord-5ccaff33a4604bc38b0a82ad5ff03cd9
Source dataset
uspto-grants-1990_02
Patent number
US04904653

Reaction notes

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