Sodium Hydroxide → HCID 19864517, compound

HRID 1200002Notes

Reaction equation

HRID 1200002 reaction equation
C([NH:4][CH2:5][CH2:6][CH2:7][CH2:8][N:9]1[C:17]2[CH:16]=[CH:15][N:14]=[CH:13][C:12]=2[N:11]=[C:10]1[CH3:18])(=O)C.[OH-].[Na+]>Cl>[CH3:18][C:10]1[N:9]([CH2:8][CH2:7][CH2:6][CH2:5][NH2:4])[C:17]2[CH:16]=[CH:15][N:14]=[CH:13][C:12]=2[N:11]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19864536HCID 19864536, compound

Product 1

HCID 19864517HCID 19864517, compoundYield 85.6%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

N-Acetyl-4-(2-methylimidazo[4,5-c]pyrid-1-yl)butylamine (1 g) was dissolved in 2M hydrochloric acid (100 ml) and heated at reflux for 8 hours. The solution was basified to pH8 with 2M sodium hydroxide solution and then extracted with methylene chloride using a continuous extractor. The organic extract was evaporated under vacuum to give the title product, (0.71 g).

Workup

  1. temperatureheated
  2. temperatureat reflux for 8 hours
  3. extractionextracted with methylene chloride using a continuous extractor
  4. extractionThe organic extract
  5. customwas evaporated under vacuum

Sources & evidence

ORD record
ord-c3fdb42302eb4449aa08e36582e76702
Source dataset
uspto-grants-1990_02
Patent number
US04904671

Reaction notes

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