Hydrochloric Acid → HCID 19864578, compound

HRID 1200030Notes

Reaction equation

HRID 1200030 reaction equation
[Na].[CH3:2][OH:3].[C:4]([C:7]1[CH:8]=[CH:9][C:10]([C:13]#[N:14])=[N:11][CH:12]=1)([OH:6])=[O:5].Cl>O>[C:4]([C:7]1[CH:8]=[CH:9][C:10]([C:13](=[NH:14])[O:3][CH3:2])=[N:11][CH:12]=1)([OH:6])=[O:5]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 27611086-Cyanopyridine-3-carboxylic acidHCID 5360545Sodium2×

Product 1

HCID 19864578HCID 19864578, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Sodium (12 mmol) is added to a flask containing 20 ml of methanol. After the sodium has dissolved, 5 mmol of 5-carboxy-2-cyano-pyridine is added. The mixture is heated at 50° for 6 h. After cooling, the reaction mixture is diluted with water and acidified (pH=5)with 2N HCl. The solid is collected and dried, and corresponds to the title compound, m.p. 284°-286°.

Workup

  1. temperatureThe mixture is heated at 50° for 6 h
  2. temperatureAfter cooling
  3. customThe solid is collected
  4. customdried

Sources & evidence

ORD record
ord-7c1f13deab944ed5ada065dc9073ac2d
Source dataset
uspto-grants-1990_02
Patent number
US04904675

Reaction notes

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