Hydroxyamine hydrochloride → HCID 136364583, compound

HRID 1200033Notes

Reaction equation

HRID 1200033 reaction equation
[Na].[C:2]([C:5]1[CH:6]=[CH:7][C:8]([C:11]#[N:12])=[N:9][CH:10]=1)([OH:4])=[O:3].Cl.[NH2:14][OH:15]>C(O)C>[C:2]([C:5]1[CH:6]=[CH:7][C:8]([C:11](=[N:14][OH:15])[NH2:12])=[N:9][CH:10]=1)([OH:4])=[O:3]

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 27611086-Cyanopyridine-3-carboxylic acidHCID 5360545Sodium2×

Product 1

HCID 136364583HCID 136364583, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Sodium (18 mmol) is added to a flask containing 20 ml of ethanol. After the sodium has dissolved, 3.8 mmol of 5-carboxy-2-cyanopyridine and 18 mmol of hydroxylamine hydrochloride are added, and the solution is refluxed for 5 h. After cooling, the resulting precipitate is filtered off and recrystallized from water; m.p.>300°.

Workup

  1. temperaturethe solution is refluxed for 5 h
  2. temperatureAfter cooling
  3. filtrationthe resulting precipitate is filtered off
  4. customrecrystallized from water

Sources & evidence

ORD record
ord-431e14a2a21948e6bbabb6164684945e
Source dataset
uspto-grants-1990_02
Patent number
US04904675

Reaction notes

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