2-Fluoro-4-(1,1,2,2-tetrafluoroethoxy)nitrobenzene → 2-Fluoro-4-(1,1,2,2-tetrafluoroethoxy)aniline

HRID 1200162Notes

Reaction equation

HRID 1200162 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([O:8][C:9]([F:14])([F:13])[CH:10]([F:12])[F:11])[CH:5]=[CH:4][C:3]=1[N+:15]([O-])=O.[H][H]>[Pt](=O)=O.C(OCC)(=O)C>[F:1][C:2]1[CH:7]=[C:6]([O:8][C:9]([F:13])([F:14])[CH:10]([F:12])[F:11])[CH:5]=[CH:4][C:3]=1[NH2:15]

Participants

5

Reactant 2

HCID 147216932-Fluoro-4-(1,1,2,2-tetrafluoroethoxy)nitrobenzeneHCID 178418361HCID 178418361, compound2×

Product 1

HCID 146245342-Fluoro-4-(1,1,2,2-tetrafluoroethoxy)anilineYield 85%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 8857Ethyl AcetateSolvent

Procedure

0.20 Gram of 2-fluoro-4-(1,1,2,2-tetrafluoroethoxy)nitrobenzene, 0.03 g of platinum dioxide and 5 ml of ethyl acetate were added to a reactor, and the atmosphere in the reactor was replaced by a hydrogen stream with stirring. Stirring was then continued at room temperature for 2 hours while introducing a hydrogen gas. Thereater, the reaction solution was filtered off, and the filtrate was concentrated to obtain 0.15 g of 2-fluoro-4-(1,1,2,2-tetrafluoroethoxy)aniline.

Workup

  1. stirringStirring
  2. filtrationThereater, the reaction solution was filtered off
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-4c38dea07e044846aaffe543e0b2fd6a
Source dataset
uspto-grants-1990_02
Patent number
US04904696

Reaction notes

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