Water → 5-(Chloromethyl)-2,2-difluorobenzo[d][1,3]dioxole

HRID 1201115Notes

Reaction equation

HRID 1201115 reaction equation
[C:19]([O:20][CH3:21])([CH3:22])([CH3:23])[CH3:24].[CH3:25][N:26]([c:27]1[cH:28][cH:29][n:30][cH:31][cH:32]1)[CH3:33].[F:1][C:2]1([F:13])[O:3][c:4]2[c:5]([cH:7][cH:8][c:9]([CH2:11][OH:12])[cH:10]2)[O:6]1.[OH2:18].[S:14]([Cl:15])([Cl:16])=[O:17]>>[F:1][C:2]1([F:13])[O:3][c:4]2[c:5]([cH:7][cH:8][c:9]([CH2:11][Cl:16])[cH:10]2)[O:6]1

Participants

6

Reactant 5

HCID 962WaterHCID 142844-(Dimethylamino)pyridineHCID 15413tert-Butyl methyl etherHCID 24386Thionyl ChlorideHCID 12814281(2,2-Difluoro-1,3-dioxaindan-5-yl)methanol

Product 1

HCID 219928095-(Chloromethyl)-2,2-difluorobenzo[d][1,3]dioxole

Sources & evidence

ORD record
ord-05db09ccd003481c8175851d632c1624
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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