Sodium ion → 8-Fluoro-5-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-5,6-dihydro-benzo[i]phenanthridin-2-ol

HRID 1201619Notes

Reaction equation

HRID 1201619 reaction equation
[BH4-:59].[C:1]([O:2][C:3](=[O:4])[NH:7][c:8]1[c:9](-[c:15]2[c:16]([C:26](=[O:5])[c:27]3[cH:28][cH:29][c:30]([O:33][CH2:34][CH2:35][N:36]4[CH2:37][CH2:38][CH2:39][CH2:40][CH2:41]4)[cH:31][cH:32]3)[c:17]3[cH:18][cH:19][c:20]([OH:25])[cH:21][c:22]3[cH:23][cH:24]2)[cH:10][cH:11][c:12]([F:14])[cH:13]1)([CH3:6])([CH3:42])[CH3:43].[C:61]([BH3-:62])#[N:63].[CH3:44][O:45][c:46]1[cH:47][cH:48][cH:49][cH:50][cH:51]1.[Cl:65][CH2:66][Cl:67].[Na+:60].[Na+:64].[OH:52][C:53]([C:54]([F:55])([F:56])[F:57])=[O:58]>>[NH:7]1[c:8]2[c:9]([cH:10][cH:11][c:12]([F:14])[cH:13]2)-[c:15]2[c:16]([c:17]3[cH:18][cH:19][c:20]([OH:25])[cH:21][c:22]3[cH:23][cH:24]2)[CH:26]1[c:27]1[cH:28][cH:29][c:30]([O:33][CH2:34][CH2:35][N:36]2[CH2:37][CH2:38][CH2:39][CH2:40][CH2:41]2)[cH:31][cH:32]1

Participants

8

Reactant 7

HCID 923Sodium ion2×HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 28123BorohydrideHCID 498716Cyano-borohydrideHCID 67004793HCID 67004793, compound

Product 1

HCID 575525218-Fluoro-5-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-5,6-dihydro-benzo[i]phenanthridin-2-ol

Sources & evidence

ORD record
ord-0cceab89478a4639bdd714cdeda5950e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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