Tetrahydrofuran → 3-[2-(3,3-Dicyclohexylureido)-thiazol-5-yl]-acrylic acid ethyl ester

HRID 1202588Notes

Reaction equation

HRID 1202588 reaction equation
[C:24](=[O:25])([O:26][CH2:27][CH3:28])[CH:29]=[P:30]([c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1)([c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1)[c:43]1[cH:44][cH:45][cH:46][cH:47][cH:48]1.[CH2:49]1[O:50][CH2:51][CH2:52][CH2:53]1.[CH:1]1([N:7]([C:8](=[O:9])[NH:10][c:11]2[s:12][c:13]([CH:16]=[O:17])[cH:14][n:15]2)[CH:18]2[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1>>[CH:1]1([N:7]([C:8](=[O:9])[NH:10][c:11]2[s:12][c:13]([CH:49]=[CH:29][C:24](=[O:25])[O:26][CH2:27][CH3:28])[cH:14][n:15]2)[CH:18]2[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 70670Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl esterHCID 578834711,1-Dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea

Product 1

HCID 767240843-[2-(3,3-Dicyclohexylureido)-thiazol-5-yl]-acrylic acid ethyl ester

Sources & evidence

ORD record
ord-a6705b92d0b044beb852357b45af1eb4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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