Tetrahydrofuran → EL 494

HRID 1202711Notes

Reaction equation

HRID 1202711 reaction equation
[CH2:12]([Li:13])[CH2:14][CH2:15][CH3:16].[Cl:17][C:18](=[O:19])[O:20][c:21]1[cH:22][cH:23][c:24]([N+:25]([O-:26])=[O:27])[cH:28][cH:29]1.[NH2:1][C:2](=[O:3])[c:4]1[c:5]([Cl:6])[cH:7][cH:8][cH:9][c:10]1[Cl:11].[NH2:30][c:31]1[n:32][c:33]([CH3:44])[c:34](-[c:37]2[cH:38][cH:39][c:40]([Br:43])[cH:41][cH:42]2)[n:35][cH:36]1.[O:45]1[CH2:46][CH2:47][CH2:48][CH2:49]1>>[NH:1]([C:2](=[O:3])[c:4]1[c:5]([Cl:6])[cH:7][cH:8][cH:9][c:10]1[Cl:11])[C:18](=[O:19])[NH:30][c:31]1[n:32][c:33]([CH3:44])[c:34](-[c:37]2[cH:38][cH:39][c:40]([Br:43])[cH:41][cH:42]2)[n:35][cH:36]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 161832,6-DichlorobenzamideHCID 821294-Nitrophenyl chloroformateHCID 127956102-Amino-5-(4-bromophenyl)-6-methylpyrazineHCID 178418339Butyllithium

Product 1

HCID 151566EL 494

Sources & evidence

ORD record
ord-ef727e50e1e74459b6499082d8de42e0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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