Dimethylformamide → HCID 178423430, compound

HRID 1203207Notes

Reaction equation

HRID 1203207 reaction equation
[Br:52][c:53]1[c:54]([CH3:55])[cH:56][c:57](-[c:58]2[n:59][cH:60][n:61]([CH:62]3[CH2:63][CH2:64][CH2:65][CH2:66][O:67]3)[n:68]2)[c:69]([F:70])[cH:71]1.[CH3:72][N:73]([CH3:74])[CH:75]=[O:76].[CH:34]([N:35]1[c:36]2[n:37][c:38]([Sn:39]([CH3:40])([CH3:41])[CH3:42])[cH:43][n:44][c:45]2[NH:46][CH2:47][C:48]1=[O:49])([CH3:50])[CH3:51].[F:1][c:2]1[c:3](-[c:23]2[n:24][n:25]([CH:28]3[CH2:29][CH2:30][CH2:31][CH2:32][O:33]3)[cH:26][n:27]2)[cH:4][c:5]([CH3:22])[c:6](-[c:8]2[cH:9][n:10][c:11]3[c:12]([n:13]2)[N:14]([CH:19]([CH3:20])[CH3:21])[C:15](=[O:18])[CH2:16][NH:17]3)[cH:7]1.[Pd:77]([Cl:78])[Cl:79].[c:80]1([P:81]([c:82]2[cH:83][cH:84][cH:85][cH:86][cH:87]2)[c:88]2[cH:89][cH:90][cH:91][cH:92][cH:93]2)[cH:94][cH:95][cH:96][cH:97][cH:98]1.[c:99]1([P:100]([c:101]2[cH:102][cH:103][cH:104][cH:105][cH:106]2)[c:107]2[cH:108][cH:109][cH:110][cH:111][cH:112]2)[cH:113][cH:114][cH:115][cH:116][cH:117]1>>[F:1][c:2]1[c:3](-[c:23]2[n:24][nH:25][cH:26][n:27]2)[cH:4][c:5]([CH3:22])[c:6](-[c:8]2[cH:9][n:10][c:11]3[c:12]([n:13]2)[N:14]([CH:19]([CH3:20])[CH3:21])[C:15](=[O:18])[CH2:16][NH:17]3)[cH:7]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 666072813-(4-bromo-2-fluoro-5-methylphenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-1,2,4-triazoleHCID 666075107-(5-Fluoro-2-methyl-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-1,2,4-triazol-3-yl)phenyl)-1-isopropyl-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-oneHCID 666080081-Isopropyl-7-(trimethylstannyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one

Product 1

HCID 178423430HCID 178423430, compound

Sources & evidence

ORD record
ord-af7654b518e74399b1a652aa882b51a8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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