Tetrahydrofuran → ethyl 3-(4-{[2',6'-dimethyl-4'-(tetrahydro-2H-thiopyran-4-yloxy)biphenyl-3-yl]methoxy}-2-fluorophenyl)propanoate

HRID 1203530Notes

Reaction equation

HRID 1203530 reaction equation
[F:1][c:2]1[c:3]([CH2:25][CH2:26][C:27](=[O:28])[O:29][CH2:30][CH3:31])[cH:4][cH:5][c:6]([O:8][CH2:9][c:10]2[cH:11][c:12](-[c:16]3[c:17]([CH3:24])[cH:18][c:19]([OH:23])[cH:20][c:21]3[CH3:22])[cH:13][cH:14][cH:15]2)[cH:7]1.[O:58]=[C:59]([O:60][CH2:61][CH3:62])[N:63]=[N:64][C:65]([O:66][CH2:67][CH3:68])=[O:69].[O:70]1[CH2:71][CH2:72][CH2:73][CH2:74]1.[S:32]1[CH2:33][CH2:34][CH:35]([OH:38])[CH2:36][CH2:37]1.[c:39]1([P:40]([c:41]2[cH:42][cH:43][cH:44][cH:45][cH:46]2)[c:47]2[cH:48][cH:49][cH:50][cH:51][cH:52]2)[cH:53][cH:54][cH:55][cH:56][cH:57]1>>[F:1][c:2]1[c:3]([CH2:25][CH2:26][C:27](=[O:28])[O:29][CH2:30][CH3:31])[cH:4][cH:5][c:6]([O:8][CH2:9][c:10]2[cH:11][c:12](-[c:16]3[c:17]([CH3:24])[cH:18][c:19]([O:23][CH:35]4[CH2:34][CH2:33][S:32][CH2:37][CH2:36]4)[cH:20][c:21]3[CH3:22])[cH:13][cH:14][cH:15]2)[cH:7]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 576296Tetrahydro-2H-thiopyran-4-olHCID 58903128Ethyl 3-{2-fluoro-4-[(4'-hydroxy-2',6'-dimethylbiphenyl-3-yl)methoxy]phenyl}propanoate

Product 1

HCID 58903212ethyl 3-(4-{[2',6'-dimethyl-4'-(tetrahydro-2H-thiopyran-4-yloxy)biphenyl-3-yl]methoxy}-2-fluorophenyl)propanoate

Sources & evidence

ORD record
ord-16a4a2963df7498692bb0dd99755fa75
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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