2-Pyrazinecarboxylic acid → N-[2-amino-2,2-bis(4-fluorophenyl)-1-methylethyl]-2-pyrazinecarboxamide

HRID 1204090Notes

Reaction equation

HRID 1204090 reaction equation
[CH3:29][N:30]([CH3:31])[CH2:32][CH2:33][CH2:34][N:35]=[C:36]=[N:37][CH2:38][CH3:39].[F:1][c:2]1[cH:3][cH:4][c:5]([C:8]([CH:9]([CH3:10])[NH2:11])([NH2:12])[c:13]2[cH:14][cH:15][c:16]([F:19])[cH:17][cH:18]2)[cH:6][cH:7]1.[cH:40]1[cH:41][cH:42][n:43][cH:44][cH:45]1.[n:20]1[c:21]([C:26](=[O:27])[OH:28])[cH:22][n:23][cH:24][cH:25]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([C:8]([CH:9]([CH3:10])[NH:11][C:26]([c:21]2[n:20][cH:25][cH:24][n:23][cH:22]2)=[O:27])([NH2:12])[c:13]2[cH:14][cH:15][c:16]([F:19])[cH:17][cH:18]2)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 10472-Pyrazinecarboxylic acidHCID 1049PyridineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 218859191,1-Bis(4-fluorophenyl)-1,2-propanediamine

Product 1

HCID 69053565N-[2-amino-2,2-bis(4-fluorophenyl)-1-methylethyl]-2-pyrazinecarboxamide

Sources & evidence

ORD record
ord-89bf3f4df99f4cbbbe5191234aacb0ff
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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