Methanol → 1-(7-(3-(hydroxymethyl)-1H-1,2,4-triazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-(4-(pyridin-2-yl)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)ethane-1,2-dione

HRID 1204984Notes

Reaction equation

HRID 1204984 reaction equation
[B-:40]([F:41])([F:42])([F:43])[F:44].[CH3:76][OH:77].[CH:62]([N:63]([CH2:64][CH3:65])[CH:66]([CH3:67])[CH3:68])([CH3:69])[CH3:70].[O:71]=[CH:72][N:73]([CH3:74])[CH3:75].[OH:1][CH2:2][c:3]1[n:4][n:5](-[c:8]2[n:9][cH:10][c:11]([O:22][CH3:23])[c:12]3[c:13]2[nH:14][cH:15][c:16]3[C:17]([C:18](=[O:19])[OH:20])=[O:21])[cH:6][n:7]1.[n:24]1[c:25](-[c:30]2[c:31]3[c:32]([n:33][cH:34][n:35]2)[CH2:36][NH:37][CH2:38][CH2:39]3)[cH:26][cH:27][cH:28][cH:29]1.[n:45]1([O:46][C:47]([N:48]([CH3:49])[CH3:50])=[N+:51]([CH3:52])[CH3:53])[c:54]2[cH:55][cH:56][cH:57][cH:58][c:59]2[n:60][n:61]1>>[OH:1][CH2:2][c:3]1[n:4][n:5](-[c:8]2[n:9][cH:10][c:11]([O:22][CH3:23])[c:12]3[c:13]2[nH:14][cH:15][c:16]3[C:17]([C:18](=[O:20])[N:37]2[CH2:36][c:32]3[c:31]([c:30](-[c:25]4[n:24][cH:29][cH:28][cH:27][cH:26]4)[n:35][cH:34][n:33]3)[CH2:39][CH2:38]2)=[O:21])[cH:6][n:7]1

Participants

8

Reactant 7

HCID 887MethanolHCID 6228DimethylformamideHCID 26255TetrafluoroborateHCID 81531DiisopropylethylamineHCID 130500O-benzotriazol-1-yl-tetramethyluroniumHCID 580260572-(7-(3-(hydroxymethyl)-1H-1,2,4-triazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acidHCID 580260644-(Pyridin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

Product 1

HCID 446028601-(7-(3-(hydroxymethyl)-1H-1,2,4-triazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-(4-(pyridin-2-yl)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)ethane-1,2-dione

Sources & evidence

ORD record
ord-5d40a89b0b1044fa81dd7445fbeabe38
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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