Dimethylformamide → tert-butyl N-[7a-[5-[(5-cyanopyridine-2-carbonyl)amino]-2-fluorophenyl]-4,4a,5,6-tetrahydrofuro[2,3-d][1,3]thiazin-2-yl]carbamate

HRID 1205489Notes

Reaction equation

HRID 1205489 reaction equation
[C:26](#[N:27])[c:28]1[cH:29][cH:30][c:31]([C:34](=[O:35])[OH:36])[n:32][cH:33]1.[CH:61]([N:62]([CH2:63][CH3:64])[CH:65]([CH3:66])[CH3:67])([CH3:68])[CH3:69].[NH2:1][c:2]1[cH:3][cH:4][c:5]([F:25])[c:6]([C:8]23[N:9]=[C:10]([NH:17][C:18]([O:19][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:24])[S:11][CH2:12][CH:13]2[CH2:14][CH2:15][O:16]3)[cH:7]1.[O:70]=[CH:71][N:72]([CH3:73])[CH3:74].[P-:37]([F:38])([F:39])([F:40])([F:41])([F:42])[F:43].[n:44]1([O:45][C:46]([N:47]([CH3:48])[CH3:49])=[N+:50]([CH3:51])[CH3:52])[c:53]2[n:54][cH:55][cH:56][cH:57][c:58]2[n:59][n:60]1>>[NH:1]([c:2]1[cH:3][cH:4][c:5]([F:25])[c:6]([C:8]23[N:9]=[C:10]([NH:17][C:18]([O:19][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:24])[S:11][CH2:12][CH:13]2[CH2:14][CH2:15][O:16]3)[cH:7]1)[C:34]([c:31]1[cH:30][cH:29][c:28]([C:26]#[N:27])[cH:33][n:32]1)=[O:35]

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 124007345-Cyanopyridine-2-carboxylic acidHCID 123188868tert-butyl N-[7a-(5-amino-2-fluorophenyl)-4,4a,5,6-tetrahydrofuro[2,3-d][1,3]thiazin-2-yl]carbamate

Product 1

HCID 123399491tert-butyl N-[7a-[5-[(5-cyanopyridine-2-carbonyl)amino]-2-fluorophenyl]-4,4a,5,6-tetrahydrofuro[2,3-d][1,3]thiazin-2-yl]carbamate

Sources & evidence

ORD record
ord-818c7db1cb2e482ca9c9d9fa547f8112
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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