Hydrochloric Acid → 5-Chloro-3-(5-dimethylamino-3H-isobenzofuran-1-ylidene)-1,3-dihydroindol-2-one

HRID 1206158Notes

Reaction equation

HRID 1206158 reaction equation
[CH2:39]([CH2:40][O:41][CH3:42])[O:43][CH3:44].[CH3:12][CH2:13][CH2:14][CH2:15][Li:16].[CH3:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22].[CH3:23][N:24]([c:25]1[cH:26][c:27]2[c:31]([cH:32][cH:33]1)[C:30](=[O:34])[O:29][CH2:28]2)[CH3:35].[CH3:45][CH2:46][O:47][C:48]([CH3:49])=[O:50].[CH3:51][OH:52].[Cl:1][c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[NH:7][C:6](=[O:11])[CH2:5]2.[ClH:36].[Na+:38].[OH-:37]>>[Cl:1][c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[NH:7][C:6](=[O:11])[C:5]2=[C:30]1[O:29][CH2:28][c:27]2[cH:26][c:25]([N:24]([CH3:23])[CH3:35])[cH:33][cH:32][c:31]21

Participants

11

Reactant 10

HCID 313Hydrochloric AcidHCID 887MethanolHCID 923Sodium ionHCID 961HydroxideHCID 8058HexaneHCID 80711,2-DimethoxyethaneHCID 8857Ethyl AcetateHCID 1528015-ChlorooxindoleHCID 34010695-DimethylaminophthalideHCID 178418339Butyllithium

Product 1

HCID 688358045-Chloro-3-(5-dimethylamino-3H-isobenzofuran-1-ylidene)-1,3-dihydroindol-2-one

Sources & evidence

ORD record
ord-bc14425ec7d646f295a129a0b92ea027
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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