Dimethylformamide → 2-{2-[2-(2-Hydroxyethoxy)ethoxy]ethyl}-1H-isoindole-1,3(2H)-dione

HRID 1206376Notes

Reaction equation

HRID 1206376 reaction equation
[C:43]1(=[O:53])[c:44]2[c:45]([cH:49][cH:50][cH:51][cH:52]2)[C:46](=[O:48])[NH:47]1.[CH3:55][N:56]([CH3:57])[CH:58]=[O:59].[Cl:33][CH2:34][CH2:35][O:36][CH2:37][CH2:38][O:39][CH2:40][CH2:41][OH:42].[K:54].[NH2:1][CH2:2][CH2:3][O:4][CH2:5][CH2:6][O:7][CH2:8][C:9]1=[C:27]([C:28]([O:29][CH2:30][CH3:31])=[O:32])[CH:18]([c:19]2[cH:20][cH:21][cH:22][c:23]([Cl:24])[c:25]2[Cl:26])[C:13]([C:14]([O:15][CH3:16])=[O:17])=[C:11]([CH3:12])[NH:10]1>>[CH2:34]([CH2:35][O:36][CH2:37][CH2:38][O:39][CH2:40][CH2:41][OH:42])[N:47]1[C:43](=[O:53])[c:44]2[c:45]([cH:49][cH:50][cH:51][cH:52]2)[C:46]1=[O:48]

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 6809PhthalimideHCID 788712-(2-(2-Chloroethoxy)ethoxy)ethanolHCID 1315323-Ethyl 5-methyl 2-{[2-(2-aminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylateHCID 5462222Potassium

Product 1

HCID 111501572-{2-[2-(2-Hydroxyethoxy)ethoxy]ethyl}-1H-isoindole-1,3(2H)-dione

Sources & evidence

ORD record
ord-ea8f3cc5c5b248268703769c8f91f25f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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