Tetrahydrofuran → Tert-butyl 4-(hydroxy(pyridin-3-yl)methyl)piperidine-1-carboxylate
Reaction equation
[Br:1][c:2]1[cH:3][n:4][cH:5][cH:6][cH:7]1.[CH2:28]1[O:29][CH2:30][CH2:31][CH2:32]1.[CH2:8]([Li:9])[CH2:10][CH2:11][CH3:12].[CH:13](=[O:14])[CH:15]1[CH2:16][CH2:17][N:18]([C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:19][CH2:20]1>>[c:2]1([CH:13]([OH:14])[CH:15]2[CH2:16][CH2:17][N:18]([C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:19][CH2:20]2)[cH:3][n:4][cH:5][cH:6][cH:7]1Participants
5
Sources & evidence
- ORD record
- ord-7d0e27d1768c4a45ba44111a23e68cc4
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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