Sodium Hydroxide → HCID 178454398, compound

HRID 12067Notes

Reaction equation

HRID 12067 reaction equation
C(N(C(C)C)CC)(C)C.[CH:10]([CH2:12][C:13]([OH:15])=O)=[CH2:11].N1C2C=CC=C(O[P+](N(C)C)(N(C)C)N(C)C)C=2N=N1.F[P-](F)(F)(F)(F)F.Cl.Cl.[N:45]1[C:53]2[CH2:52][CH2:51][NH:50][CH2:49][C:48]=2[S:47][C:46]=1[NH:54][C:55]([NH2:57])=[NH:56].[OH-].[Na+]>CN(C)C=O>[C:13]([N:50]1[CH2:51][CH2:52][C:53]2[N:45]=[C:46]([NH:54][C:55]([NH2:57])=[NH:56])[S:47][C:48]=2[CH2:49]1)(=[O:15])[CH2:12][CH:10]=[CH2:11]

Participants

7

Reactant 5

HCID 14798Sodium HydroxideHCID 327433-Butenoic acidHCID 81531DiisopropylethylamineHCID 178478794HCID 178478794, compoundHCID 178486078HCID 178486078, compound

Product 1

HCID 178454398HCID 178454398, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Diisopropylethylamine (0.22 mmol), vinyl acetic acid (0.11 mmol) and benzotriazolyloxy-tris-(dimethylamino)phosphonium-hexafluorophosphate (0.11 mmol) are added successively to a stirred suspension of N-(4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine-2-yl)-guanidine-dihydrochloride (0.1 mmol) in dimethylformamide (0.7 mL), and the reaction mixture is stirred for 16 hours at room temperature. After the addition of 2M caustic soda solution (1 ml) there is extraction with ethyl acetate. The combined organic phases produce the pure title compound after drying over sodium sulphate and concentrating to dryness.

Workup

  1. extractionextraction with ethyl acetate

Sources & evidence

ORD record
ord-fecbe090558448a4a06f30a565bfc4fc
Source dataset
uspto-grants-2010_06
Patent number
US07727979B2

Reaction notes

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