Tetrahydrofuran → 2-(3-Fluorophenyl)-2-methylpyrrolidine

HRID 1207026Notes

Reaction equation

HRID 1207026 reaction equation
[C:16]([c:17]1[cH:18][cH:19][c:20](-[c:21]2[cH:22][cH:23][c:24]([C:25]([CH3:26])([CH3:27])[CH3:28])[cH:29][cH:30]2)[cH:31][cH:32]1)([CH3:33])([CH3:34])[CH3:35].[CH2:36]1[O:37][CH2:38][CH2:39][CH2:40]1.[Cl:1][CH2:2][CH2:3][CH2:4][N:5]=[C:6]([CH3:7])[c:8]1[cH:9][c:10]([F:14])[cH:11][cH:12][cH:13]1.[Li:15]>>[CH2:2]1[CH2:3][CH2:4][NH:5][C:6]1([CH3:7])[c:8]1[cH:9][c:10]([F:14])[cH:11][cH:12][cH:13]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylHCID 3028194LithiumHCID 58335777HCID 58335777, compound

Product 1

HCID 583355042-(3-Fluorophenyl)-2-methylpyrrolidine

Sources & evidence

ORD record
ord-5cb88aa21c0b48339f66fda103178311
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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