Hydrochloric Acid → 4-[({4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}methyl)(methyl)amino]-1-(methylsulfonyl)piperidine-4-carboxamide

HRID 1207974Notes

Reaction equation

HRID 1207974 reaction equation
[CH3:1][S:2]([Cl:3])(=[O:4])=[O:5].[CH3:40][CH2:41][N:42]([CH2:43][CH3:44])[CH2:45][CH3:46].[Cl:47][CH2:48][Cl:49].[Cl:7][c:8]1[c:9]([F:39])[c:10]([NH:14][c:15]2[n:16][cH:17][n:18][c:19]3[cH:20][c:21]([O:37][CH3:38])[c:22]([CH2:25][N:26]([C:27]4([C:33](=[O:34])[NH2:35])[CH2:28][CH2:29][NH:30][CH2:31][CH2:32]4)[CH3:36])[cH:23][c:24]23)[cH:11][cH:12][cH:13]1.[ClH:6]>>[CH3:1][S:2](=[O:4])(=[O:5])[N:30]1[CH2:29][CH2:28][C:27]([N:26]([CH2:25][c:22]2[c:21]([O:37][CH3:38])[cH:20][c:19]3[n:18][cH:17][n:16][c:15]([NH:14][c:10]4[c:9]([F:39])[c:8]([Cl:7])[cH:13][cH:12][cH:11]4)[c:24]3[cH:23]2)[CH3:36])([C:33](=[O:34])[NH2:35])[CH2:32][CH2:31]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 57979867HCID 57979867, compound

Product 1

HCID 579798374-[({4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}methyl)(methyl)amino]-1-(methylsulfonyl)piperidine-4-carboxamide

Sources & evidence

ORD record
ord-66c33a2d359749b4b1a087634fd0ab93
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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