Methanol → 1-(7-(3-(1-hydroxyethyl)-1H-1,2,4-triazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-(4-(pyridin-2-yl)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)ethane-1,2-dione

HRID 1208617Notes

Reaction equation

HRID 1208617 reaction equation
[B-:41]([F:42])([F:43])([F:44])[F:45].[CH3:77][OH:78].[CH:63]([N:64]([CH2:65][CH3:66])[CH:67]([CH3:68])[CH3:69])([CH3:70])[CH3:71].[O:72]=[CH:73][N:74]([CH3:75])[CH3:76].[OH:1][CH:2]([CH3:3])[c:4]1[n:5][n:6](-[c:9]2[n:10][cH:11][c:12]([O:23][CH3:24])[c:13]3[c:14]2[nH:15][cH:16][c:17]3[C:18]([C:19](=[O:20])[OH:21])=[O:22])[cH:7][n:8]1.[n:25]1[c:26](-[c:31]2[c:32]3[c:33]([n:34][cH:35][n:36]2)[CH2:37][NH:38][CH2:39][CH2:40]3)[cH:27][cH:28][cH:29][cH:30]1.[n:46]1([O:47][C:48]([N:49]([CH3:50])[CH3:51])=[N+:52]([CH3:53])[CH3:54])[c:55]2[cH:56][cH:57][cH:58][cH:59][c:60]2[n:61][n:62]1>>[OH:1][CH:2]([CH3:3])[c:4]1[n:5][n:6](-[c:9]2[n:10][cH:11][c:12]([O:23][CH3:24])[c:13]3[c:14]2[nH:15][cH:16][c:17]3[C:18]([C:19](=[O:21])[N:38]2[CH2:37][c:33]3[c:32]([c:31](-[c:26]4[n:25][cH:30][cH:29][cH:28][cH:27]4)[n:36][cH:35][n:34]3)[CH2:40][CH2:39]2)=[O:22])[cH:7][n:8]1

Participants

8

Reactant 7

HCID 887MethanolHCID 6228DimethylformamideHCID 26255TetrafluoroborateHCID 81531DiisopropylethylamineHCID 130500O-benzotriazol-1-yl-tetramethyluroniumHCID 580260644-(Pyridin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidineHCID 580260672-(7-(3-(1-hydroxyethyl)-1H-1,2,4-triazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid

Product 1

HCID 446028611-(7-(3-(1-hydroxyethyl)-1H-1,2,4-triazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-(4-(pyridin-2-yl)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)ethane-1,2-dione

Sources & evidence

ORD record
ord-0603d369d62a4668b6db0c3953d0881b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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