Water → 1-Benzoyl-3-[1-(2-[1,4-benzodioxan-2-yl]-2-oxoethyl)piperid-4-yl]-urea

HRID 1209273Notes

Reaction equation

HRID 1209273 reaction equation
[Br:19][CH2:20][C:21](=[O:22])[CH:23]1[CH2:24][O:25][c:26]2[c:27]([cH:29][cH:30][cH:31][cH:32]2)[O:28]1.[C:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)(=[O:8])[NH:9][C:10](=[O:11])[NH:12][CH:13]1[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]1.[CH3:33][CH2:34][N:35]([CH2:36][CH3:37])[CH2:38][CH3:39].[CH3:41][N:42]([CH3:43])[CH:44]=[O:45].[OH2:40]>>[C:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)(=[O:8])[NH:9][C:10](=[O:11])[NH:12][CH:13]1[CH2:14][CH2:15][N:16]([CH2:20][C:21](=[O:22])[CH:23]2[CH2:24][O:25][c:26]3[c:27]([cH:29][cH:30][cH:31][cH:32]3)[O:28]2)[CH2:17][CH2:18]1

Participants

6

Reactant 5

HCID 962WaterHCID 6228DimethylformamideHCID 8471TriethylamineHCID 126085824-BenzoylureidopiperidineHCID 126085852-Bromo-1-(2,3-dihydro-1,4-benzodioxin-2-yl)ethan-1-one

Product 1

HCID 126085861-Benzoyl-3-[1-(2-[1,4-benzodioxan-2-yl]-2-oxoethyl)piperid-4-yl]-urea

Sources & evidence

ORD record
ord-5a12f9ea05734d17b39796435644e632
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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