Propargyl alcohol → 4-[6-(3-Hydroxy-prop-1-ynyl)-quinazolin-4-yl]-piperidine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Reaction equation
[CH2:31]([C:32]#[CH:33])[OH:34].[CH2:35]([NH:36][CH2:37][CH3:38])[CH3:39].[CH:1]([CH3:2])([CH3:3])[O:4][c:5]1[cH:6][cH:7][c:8]([NH:11][C:12](=[O:13])[N:14]2[CH2:15][CH2:16][CH:17]([c:20]3[n:21][cH:22][n:23][c:24]4[cH:25][cH:26][c:27]([I:30])[cH:28][c:29]34)[CH2:18][CH2:19]2)[cH:9][cH:10]1.[Cu:40][I:41]>>[CH:1]([CH3:2])([CH3:3])[O:4][c:5]1[cH:6][cH:7][c:8]([NH:11][C:12](=[O:13])[N:14]2[CH2:15][CH2:16][CH:17]([c:20]3[n:21][cH:22][n:23][c:24]4[cH:25][cH:26][c:27]([C:33]#[C:32][CH2:31][OH:34])[cH:28][c:29]34)[CH2:18][CH2:19]2)[cH:9][cH:10]1Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-934c144ed77c4e7cad8bcd66a0a3f1b1
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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