Dimethylformamide → N-(4-((3-Chloro-2-((diphenylmethylene)amino)pyridin-4-yl)oxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide

HRID 1209840Notes

Reaction equation

HRID 1209840 reaction equation
[CH:72]([N:73]([CH2:74][CH3:75])[CH:76]([CH3:77])[CH3:78])([CH3:79])[CH3:80].[F:31][c:32]1[cH:33][cH:34][c:35](-[c:38]2[c:39](=[O:47])[c:40]([C:44](=[O:45])[OH:46])[cH:41][nH:42][cH:43]2)[cH:36][cH:37]1.[NH2:1][c:2]1[cH:3][c:4]([F:30])[c:5]([O:6][c:7]2[c:8]([Cl:27])[c:9]([N:13]=[C:14]([c:15]3[cH:16][cH:17][cH:18][cH:19][cH:20]3)[c:21]3[cH:22][cH:23][cH:24][cH:25][cH:26]3)[n:10][cH:11][cH:12]2)[cH:28][cH:29]1.[O:81]=[CH:82][N:83]([CH3:84])[CH3:85].[P-:48]([F:49])([F:50])([F:51])([F:52])([F:53])[F:54].[n:55]1([O:56][C:57]([N:58]([CH3:59])[CH3:60])=[N+:61]([CH3:62])[CH3:63])[c:64]2[n:65][cH:66][cH:67][cH:68][c:69]2[n:70][n:71]1>>[NH:1]([c:2]1[cH:3][c:4]([F:30])[c:5]([O:6][c:7]2[c:8]([Cl:27])[c:9]([N:13]=[C:14]([c:15]3[cH:16][cH:17][cH:18][cH:19][cH:20]3)[c:21]3[cH:22][cH:23][cH:24][cH:25][cH:26]3)[n:10][cH:11][cH:12]2)[cH:28][cH:29]1)[C:44]([c:40]1[c:39](=[O:47])[c:38](-[c:35]2[cH:34][cH:33][c:32]([F:31])[cH:37][cH:36]2)[cH:43][nH:42][cH:41]1)=[O:45]

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 581336014-(4-amino-2-fluorophenoxy)-3-chloro-N-(diphenylmethylene)pyridin-2-amineHCID 602042075-(4-Fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

Product 1

HCID 86650689N-(4-((3-Chloro-2-((diphenylmethylene)amino)pyridin-4-yl)oxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide

Sources & evidence

ORD record
ord-8368efb711b04e57a443aebafdce1aa2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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