Dimethylformamide → 5-{3-[4-(4-Chloro-phenyl)-4-hydroxy-3-methyl-piperidin-1-yl]-propylidene}-5,11-dihydro-10-oxa-1-aza-dibenzo[a,d]cyclohepten-7-ol

HRID 1209891Notes

Reaction equation

HRID 1209891 reaction equation
[Br:23][CH2:24][CH2:25][CH:26]=[C:27]1[c:28]2[c:29]([cH:38][cH:39][c:40]([OH:42])[cH:41]2)[O:30][CH2:31][c:32]2[c:33]1[cH:34][cH:35][cH:36][n:37]2.[CH3:16][CH2:17][N:18]([CH2:19][CH3:20])[CH2:21][CH3:22].[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:8]2([OH:15])[CH:9]([CH3:14])[CH2:10][NH:11][CH2:12][CH2:13]2)[cH:6][cH:7]1.[O:43]=[CH:44][N:45]([CH3:46])[CH3:47]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:8]2([OH:15])[CH:9]([CH3:14])[CH2:10][N:11]([CH2:24][CH2:25][CH:26]=[C:27]3[c:28]4[c:29]([cH:38][cH:39][c:40]([OH:42])[cH:41]4)[O:30][CH2:31][c:32]4[c:33]3[cH:34][cH:35][cH:36][n:37]4)[CH2:12][CH2:13]2)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 231370704-(4-Chloro-phenyl)-3-methyl-piperidin-4-olHCID 667586405-(3-Bromo-propylidene)-5,11-dihydro-10-oxa-1-aza-dibenzo[a,d]cyclohepten-7-ol

Product 1

HCID 536307665-{3-[4-(4-Chloro-phenyl)-4-hydroxy-3-methyl-piperidin-1-yl]-propylidene}-5,11-dihydro-10-oxa-1-aza-dibenzo[a,d]cyclohepten-7-ol

Sources & evidence

ORD record
ord-38c2fff2101245459991679f7b876779
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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