Water → 2-chloro-3-(1-cyanocyclopropyl)-N-[5-({2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}oxy)-2,4-difluorophenyl]benzamide
Reaction equation
[CH3:42][N:43]([CH3:44])[c:45]1[cH:46][cH:47][n:48][cH:49][cH:50]1.[CH:35]1([C:38](=[O:39])[Cl:40])[CH2:36][CH2:37]1.[NH2:1][c:2]1[s:3][c:4]2[n:5][c:6]([O:11][c:12]3[c:13]([F:34])[cH:14][c:15]([F:33])[c:16]([NH:18][C:19]([c:20]4[c:21]([Cl:31])[c:22]([C:26]5([C:29]#[N:30])[CH2:27][CH2:28]5)[cH:23][cH:24][cH:25]4)=[O:32])[cH:17]3)[cH:7][cH:8][c:9]2[n:10]1.[OH2:41].[cH:51]1[cH:52][cH:53][n:54][cH:55][cH:56]1>>[NH:1]([c:2]1[s:3][c:4]2[n:5][c:6]([O:11][c:12]3[c:13]([F:34])[cH:14][c:15]([F:33])[c:16]([NH:18][C:19]([c:20]4[c:21]([Cl:31])[c:22]([C:26]5([C:29]#[N:30])[CH2:27][CH2:28]5)[cH:23][cH:24][cH:25]4)=[O:32])[cH:17]3)[cH:7][cH:8][c:9]2[n:10]1)[C:38]([CH:35]1[CH2:36][CH2:37]1)=[O:39]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-f68daead57504d46be104b122398fecc
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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