Dimethylformamide → 3-[1-[4-[4-(4-Fluorophenyl)-5-pyrimidin-4-ylimidazol-1-yl]piperidin-1-yl]ethyl]-1,2-oxazole

HRID 1210143Notes

Reaction equation

HRID 1210143 reaction equation
[C:13](=[O:14])([O-:15])[O-:16].[CH3:1][S:2]([O:3][CH:6]([CH3:7])[c:8]1[n:9][o:10][cH:11][cH:12]1)(=[O:4])=[O:5].[CH3:43][CH2:44][O:45][C:46](=[O:47])[CH3:48].[Cs+:17].[Cs+:18].[F:19][c:20]1[cH:21][cH:22][c:23](-[c:26]2[n:27][cH:28][n:29]([CH:37]3[CH2:38][CH2:39][NH:40][CH2:41][CH2:42]3)[c:30]2-[c:31]2[n:32][cH:33][n:34][cH:35][cH:36]2)[cH:24][cH:25]1.[O:49]=[CH:50][N:51]([CH3:52])[CH3:53]>>[CH:6]([CH3:7])([c:8]1[n:9][o:10][cH:11][cH:12]1)[N:40]1[CH2:39][CH2:38][CH:37]([n:29]2[cH:28][n:27][c:26](-[c:23]3[cH:22][cH:21][c:20]([F:19])[cH:25][cH:24]3)[c:30]2-[c:31]2[n:32][cH:33][n:34][cH:35][cH:36]2)[CH2:42][CH2:41]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 574617131-Isoxazol-3-ylethyl methanesulfonateHCID 574617184-[4-(4-Fluorophenyl)-1-piperidin-4-yl-1H-imidazol-5-yl]pyrimidine

Product 1

HCID 671045863-[1-[4-[4-(4-Fluorophenyl)-5-pyrimidin-4-ylimidazol-1-yl]piperidin-1-yl]ethyl]-1,2-oxazole

Sources & evidence

ORD record
ord-f698d855fdcb412ba622d725f6ffda63
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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