Water → N-(4-Chlorobenzyl)-2-(((2-hydroxy-2-pyridin-3-ylethyl)(methyl)amino)methyl)-7-methyl-4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamide

HRID 1212281Notes

Reaction equation

HRID 1212281 reaction equation
[CH3:10][NH:11][CH2:12][CH:13]([OH:14])[c:15]1[cH:16][n:17][cH:18][cH:19][cH:20]1.[CH:1]([N:2]([CH2:3][CH3:4])[CH:5]([CH3:6])[CH3:7])([CH3:8])[CH3:9].[Cl:21][c:22]1[cH:23][cH:24][c:25]([CH2:26][NH:27][C:28](=[O:29])[c:30]2[c:31](=[O:42])[c:32]3[c:33]([n:34]([CH3:36])[cH:35]2)[o:37][c:38]([CH2:40][Cl:41])[cH:39]3)[cH:43][cH:44]1.[O:46]=[CH:47][N:48]([CH3:49])[CH3:50].[OH2:45]>>[CH3:10][N:11]([CH2:12][CH:13]([OH:14])[c:15]1[cH:16][n:17][cH:18][cH:19][cH:20]1)[CH2:40][c:38]1[o:37][c:33]2[c:32]([c:31](=[O:42])[c:30]([C:28]([NH:27][CH2:26][c:25]3[cH:24][cH:23][c:22]([Cl:21])[cH:44][cH:43]3)=[O:29])[cH:35][n:34]2[CH3:36])[cH:39]1

Participants

6

Reactant 5

HCID 962WaterHCID 6228DimethylformamideHCID 81531DiisopropylethylamineHCID 10126210N-(4-Chlorobenzyl)-2-(chloromethyl)-7-methyl-4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamideHCID 224987342-(Methylamino)-1-(pyridin-3-yl)ethan-1-ol

Product 1

HCID 10128013N-(4-Chlorobenzyl)-2-(((2-hydroxy-2-pyridin-3-ylethyl)(methyl)amino)methyl)-7-methyl-4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamide

Sources & evidence

ORD record
ord-ca66b79391d4427b9201f024c9508f8a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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