Dichloromethane → 8-bromo-N-(2-chloro-4-(4-methylpiperazine-1-carbonyl)phenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide
Reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:29]1)[O:7][CH2:8][CH2:9][c:10]1[c:11]-2[s:12][c:13]([C:15](=[O:16])[N:17]([CH3:18])[c:19]2[c:20]([Cl:28])[cH:21][c:22]([C:23](=[O:24])[OH:25])[cH:26][cH:27]2)[cH:14]1.[CH2:30]([Cl:31])[Cl:32].[CH3:33][N:34]1[CH2:35][CH2:36][NH:37][CH2:38][CH2:39]1.[CH:40]([N:41]([CH2:42][CH3:43])[CH:44]([CH3:45])[CH3:46])([CH3:47])[CH3:48].[P-:49]([F:50])([F:51])([F:52])([F:53])([F:54])[F:55].[n:56]1([O:57][C:58]([N:59]([CH3:60])[CH3:61])=[N+:62]([CH3:63])[CH3:64])[c:65]2[cH:66][cH:67][cH:68][cH:69][c:70]2[n:71][n:72]1>>[Br:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:29]1)[O:7][CH2:8][CH2:9][c:10]1[c:11]-2[s:12][c:13]([C:15](=[O:16])[N:17]([CH3:18])[c:19]2[c:20]([Cl:28])[cH:21][c:22]([C:23](=[O:25])[N:37]3[CH2:36][CH2:35][N:34]([CH3:33])[CH2:39][CH2:38]3)[cH:26][cH:27]2)[cH:14]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-fa4ed7d8f84b4f30acf3edee53650e4f
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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