Dichloromethane → 7-Chloro-5-piperidin-4-ylmethyl-2-(4-trifluoromethoxy-benzyl)-2,3-dihydro-isoindol-1-one

HRID 1213451Notes

Reaction equation

HRID 1213451 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][c:15]2[cH:16][c:17]3[c:21]([c:22]([Cl:24])[cH:23]2)[C:20](=[O:25])[N:19]([CH2:26][c:27]2[cH:28][cH:29][c:30]([O:33][C:34]([F:35])([F:36])[F:37])[cH:31][cH:32]2)[CH2:18]3)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:45][CH2:46][Cl:47].[OH:38][C:39]([C:40]([F:41])([F:42])[F:43])=[O:44]>>[NH:8]1[CH2:9][CH2:10][CH:11]([CH2:14][c:15]2[cH:16][c:17]3[c:21]([c:22]([Cl:24])[cH:23]2)[C:20](=[O:25])[N:19]([CH2:26][c:27]2[cH:28][cH:29][c:30]([O:33][C:34]([F:35])([F:36])[F:37])[cH:31][cH:32]2)[CH2:18]3)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 579496974-[7-Chloro-1-oxo-2-(4-trifluoromethoxy-benzyl)-2,3-dihydro-1H-isoindol-5-ylmethyl]-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 579492977-Chloro-5-piperidin-4-ylmethyl-2-(4-trifluoromethoxy-benzyl)-2,3-dihydro-isoindol-1-one

Sources & evidence

ORD record
ord-05b66b4275994c1b8ae8db26e2c81674
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

Loading…