Dimethylformamide → 8-(1-Ethyl-propyl)-2,6-dimethyl-3-(5-fluoro-3-methyl-benzo[b]thiophen-2-yl)-imidazo[1,2-b]pyridazine

HRID 1214553Notes

Reaction equation

HRID 1214553 reaction equation
[Br:17][c:18]1[c:19]([CH3:28])[c:20]2[c:21]([s:22]1)[cH:23][cH:24][c:25]([F:27])[cH:26]2.[C:48](=[O:49])([O-:50])[O-:51].[CH2:1]([CH3:2])[CH:3]([CH2:4][CH3:5])[c:6]1[c:7]2[n:8]([n:9][c:10]([CH3:12])[cH:11]1)[cH:13][c:14]([CH3:16])[n:15]2.[Cs+:52].[Cs+:53].[O:54]=[CH:55][N:56]([CH3:57])[CH3:58].[c:29]1([P:30]([c:31]2[cH:32][cH:33][cH:34][cH:35][cH:36]2)[c:37]2[cH:38][cH:39][cH:40][cH:41][cH:42]2)[cH:43][cH:44][cH:45][cH:46][cH:47]1>>[CH2:1]([CH3:2])[CH:3]([CH2:4][CH3:5])[c:6]1[c:7]2[n:8]([n:9][c:10]([CH3:12])[cH:11]1)[c:13](-[c:18]1[c:19]([CH3:28])[c:20]3[c:21]([s:22]1)[cH:23][cH:24][c:25]([F:27])[cH:26]3)[c:14]([CH3:16])[n:15]2

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 11776TriphenylphosphineHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 667212022-Bromo-5-fluoro-3-methylbenzo[b]thiopheneHCID 688412672,6-Dimethyl-8-(pentan-3-yl)imidazo[1,2-b]pyridazine

Product 1

HCID 577525998-(1-Ethyl-propyl)-2,6-dimethyl-3-(5-fluoro-3-methyl-benzo[b]thiophen-2-yl)-imidazo[1,2-b]pyridazine

Sources & evidence

ORD record
ord-5cc63ea217cd41bf9a33255b97adefdb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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