Toluene → Tert-butyl 4-(4-chloro-1H-pyrazolo[3,4-D]pyrimidin-1-YL)piperidine-1-carboxylate

HRID 1214887Notes

Reaction equation

HRID 1214887 reaction equation
[C:20](=[O:21])([O:22][C:23]([CH3:24])([CH3:25])[CH3:26])[N:27]1[CH2:28][CH2:29][CH:30]([OH:33])[CH2:31][CH2:32]1.[CH3:49][c:50]1[cH:51][cH:52][cH:53][cH:54][cH:55]1.[Cl:34][c:35]1[c:36]2[c:37]([n:38][cH:39][n:40]1)[nH:41][n:42][cH:43]2.[O:44]1[CH2:45][CH2:46][CH2:47][CH2:48]1.[c:1]1([P:2]([c:3]2[cH:4][cH:5][cH:6][cH:7][cH:8]2)[c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)[cH:15][cH:16][cH:17][cH:18][cH:19]1>>[C:20](=[O:21])([O:22][C:23]([CH3:24])([CH3:25])[CH3:26])[N:27]1[CH2:28][CH2:29][CH:30]([n:41]2[c:37]3[c:36]([c:35]([Cl:34])[n:40][cH:39][n:38]3)[cH:43][n:42]2)[CH2:31][CH2:32]1

Participants

6

Reactant 5

HCID 1140TolueneHCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 2210954-Chloro-1H-pyrazolo[3,4-d]pyrimidineHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylate

Product 1

HCID 57964905Tert-butyl 4-(4-chloro-1H-pyrazolo[3,4-D]pyrimidin-1-YL)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-bfdccadd4d6c4fae97cf6da4dac65124
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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