Tetrahydrofuran → 2-(2,6-difluorophenyl)-4-(4-chlorophenyl)-5,6-dihydro-4H-1,3-oxazine

HRID 1217059Notes

Reaction equation

HRID 1217059 reaction equation
[CH3:1][S:2](=[O:3])(=[O:4])[Cl:5].[CH3:28][CH2:29][N:30]([CH2:31][CH3:32])[CH2:33][CH3:34].[F:6][c:7]1[c:8]([C:9](=[O:10])[NH:11][CH:12]([CH2:13][CH2:14][OH:15])[c:16]2[cH:17][cH:18][c:19]([Cl:22])[cH:20][cH:21]2)[c:23]([F:27])[cH:24][cH:25][cH:26]1.[O:35]1[CH2:36][CH2:37][CH2:38][CH2:39]1>>[F:6][c:7]1[c:8]([C:9]2=[N:11][CH:12]([c:16]3[cH:17][cH:18][c:19]([Cl:22])[cH:20][cH:21]3)[CH2:13][CH2:14][O:15]2)[c:23]([F:27])[cH:24][cH:25][cH:26]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 15790732N-(2,6-difluorobenzoyl)-3-amino-3-(4-chlorophenyl) 1-propanol

Product 1

HCID 157907332-(2,6-difluorophenyl)-4-(4-chlorophenyl)-5,6-dihydro-4H-1,3-oxazine

Sources & evidence

ORD record
ord-d3dd3fb07d444aaea0c3ab1973a958c9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

Loading…